NSUN5 Mediates Resistance to Doxorubicin via Up-regulation of DNA Damage Repair Proteins BRCA2 and BRIP1 in Colorectal Cancer.

ABSTRACT: Despite advancements in diagnosis and therapy, chemotherapy resistance and metastasis remain significant challenges for colorectal cancer (CRC) patients. Addressing resistance to cell death is crucial for improving cancer treatment outcomes. NOP2/Sun RNA methyltransferase 5 (NSUN5) has been implicated in cancers, but its role in chemotherapy resistance in CRC remains unclear. This study revealed that NSUN5 was highly expressed in CRC through bioinformatics analysis and validation with local cohort. High expression of NSUN5 predicted poorer disease-free survival in CRC patients. Nsun5^-/- mice exhibited reduced tumor incidence and malignancy in the AOM/DSS-induced CRC model. Knockdown or knockout of NSUN5 resulted in diminished proliferation and migration in CRC cell lines, effect

SUBMITTER: Xu Y 

PROVIDER: S-EPMC12597550 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature