Endothelial Cell Stimulator of Interferon Genes Regulates IL-6 Production and Is Required for Pathologic Cardiac Hypertrophy and Contractile Dysfunction in Experimental Heart Failure.

ABSTRACT: Capillary rarefaction and cardiomyocyte (CM) hypertrophy are hallmarks of the complex syndrome of heart failure (HF), a leading cause of hospitalization and death. Molecular signals within and between cellular components of the heart have emerged as central hubs that modulate cardiac pathophysiology. The stimulator of interferon genes (STING) was highly expressed in human and mouse cardiac endothelial cells (ECs) and was activated at the onset of HF. Global and inducible EC-specific STING^-/- mice were used to demonstrate that EC STING is required for contractile dysfunction in an experimental model of HF induced by transverse aortic constriction, through the regulation of CM hypertrophy and capillary rarefaction. ECs from EC-STING^-/- mice subjected to transverse aorti

SUBMITTER: Sanders E 

PROVIDER: S-EPMC12597551 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature