Association of Anti-Ro52 Seropositive Interstitial Lung Disease With a Higher Risk of Disease Progression and Mortality.

ABSTRACT:

Background

Identifying biomarkers is vital for interstitial lung disease (ILD) management and prognostication. Although anti-Ro52 antibodies frequently are detected in autoimmune diseases, their significance in ILD remains unclear.

Research question

What is the prognostic significance of anti-Ro52 antibody positivity in patients with ILD?

Study design and methods

This retrospective cohort study used an ILD registry of patients seen at an academic tertiary hospital's ILD clinic between 2015 and 2024. All patients with a diagnosis of ILD and tested for anti-Ro52 antibody status were divided into anti-Ro52 positive and negative groups. The primary outcome was ILD progression or all-cause death. ILD progression was defined as any of the following: hospitalization because

SUBMITTER: Imai R 

PROVIDER: S-EPMC12597573 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature