Timing of Screening Benefit for Lung Cancer With Low-Dose CT Imaging.

ABSTRACT:

Background

Increasing evidence supports lung cancer screening with low-dose CT (LDCT) imaging. However, the benefits of LDCT screening for lung cancer may not be immediate, making it unlikely to benefit patients with limited life expectancy.

Research question

What is the time to benefit (TTB) from LDCT screening for individuals at high risk for lung cancer?

Study design and methods

Population-based randomized controlled trials of lung cancer screening using LDCT imaging and reporting mortality outcomes were systematically searched in PubMed. TTB was estimated for the National Lung Screening Trial (NLST) and the pooled data from 4 trials using an established analysis framework.

Results

This analysis included 4 trials encompassing 64,105 individuals. In the NLST

SUBMITTER: Xie Y 

PROVIDER: S-EPMC12597576 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature