Network pharmacology and experimental validation reveal clotrimazole alleviates dextran sulfate sodium-induced ulcerative colitis by inhibiting intestinal senescence.

ABSTRACT: Ulcerative colitis (UC) is one of the spontaneous inflammatory bowel disease, which is characterized by chronic and relapsing intestinal mucosal inflammation that principally affects the colon. Chronic inflammation is a hallmark of senescent tissues, and intestinal tissue gradually appears injured with the occurrence of senescence. Therefore, senescence may aggravate the severity of UC. However, little is known about the relationship between UC and senescence. Clotrimazole (CTZ) is a synthetic azole broad-spectrum antifungal drug that has been also reported to have anti-inflammatory and anticarcinogenic effects. However, little research is available about CTZ therapeutic role and underlying mechanisms on UC and senescence. In this study, we identified that dextran sulfate sodium (DSS), a w

SUBMITTER: Chen C 

PROVIDER: S-EPMC12597641 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature