The influence of peripheral glucose on sleep brain oscillations.

ABSTRACT:

Study objectives

Previous research indicates a coupling of sleep-associated brain activity to peripheral glucose levels, such that ripple activity, a sign of increased hippocampal memory processing, is followed within 10 min by a dip in peripheral glucose levels. Whether there is respective negative feedback to the brain of peripheral glucose levels, or associated metabolic signaling, during sleep is not clear.

Methods

We tested the effects of systemic glucose administration as well as the effects of fasting (for 6 h vs. ad libitum feeding) on sleep and oscillatory signatures of memory processing during sleep, i.e. hippocampal ripples, cortical spindles and slow oscillations (SOs), using electroencephalography (EEG) from skull and local field potential recordings (LFP) from

SUBMITTER: Lun Y 

PROVIDER: S-EPMC12597666 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature