Initial experience of spatially fractionated lattice radiation therapy for palliative treatment of pediatric bulky tumors.

ABSTRACT:

Purpose

Spatially fractionated radiation therapy (SFRT) has demonstrated high clinical response rates with minimal toxicity in adult patients with bulky tumors, including radioresistant histologies. However, there is limited clinical data on SFRT in pediatric patients, and optimal techniques and dose regimens remain unclear. This study presents our single-institution experience with SFRT for the palliative treatment of bulky pediatric tumors.

Methods and materials

A retrospective review was conducted on six pediatric patients with metastatic or unresectable bulky tumors treated with SFRT. SFRT was delivered using VMAT in the form of Lattice Radiation Therapy (LRT). SFRT fraction doses ranged from 10-15 Gy, with 7-26 high-dose vertices per treatment. Sequential conventional e

SUBMITTER: Zhang H 

PROVIDER: S-EPMC12597734 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature