Investigating the causal role of cellular senescence-related genes in preeclampsia: a multi-omics Mendelian randomization study with differential expression analysis.

ABSTRACT:

Background

The causal role of cellular senescence in preeclampsia pathogenesis is not fully established. This study aimed to systematically prioritize key senescence-related genes potentially driving preeclampsia using a Mendelian randomization (MR) framework.

Results

We integrated genome-wide association studies (GWAS) of preeclampsia with expression, methylation, and proteomic quantitative trait loci (eQTLs/mQTLs/pQTLs) data for 866 senescence-related genes. Summary-data-based MR (SMR) coupled with the HEIDI (Heterogeneity in Dependent Instruments) test were used to assess causal associations and pleiotropy. Colocalization analysis evaluated shared genetic variants between QTLs and preeclampsia GWAS signals. Significant MR findings were explored for replication in an indep

SUBMITTER: Zhu H 

PROVIDER: S-EPMC12597756 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature