Engineered multifunctional transforming growth factor-β type II receptor ectodomain fusions for oncology applications.

ABSTRACT:

Introduction

The transforming growth factor-β (TGF-β) superfamily consists of a large number of evolutionarily conserved and structurally related polypeptide growth factors. TGF-β elicits a wide range of context-dependent cellular responses that play important roles in the maintenance of normal physiological processes and is implicated in various pathologies, including cancer. In healthy cells and in the early stages of cancer development, TGF-β acts as a tumor suppressor by inducing cell cycle arrest and apoptosis. However, in late-stage cancer cells, TGF-β can promote tumorigenesis, including epithelial-mesenchymal transition (EMT), metastasis and chemoresistance.

Methods

The dual-function and pleiotropic nature of TGF-β makes therapeutic targeting of this molecule a signi

SUBMITTER: Lenferink AEG 

PROVIDER: S-EPMC12597760 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature