The Association of Mixed Mineral Intake Exposure With Gout: A National Cross-Sectional National Health and Nutrition Examination Survey (NHANES) Study.

ABSTRACT: Minerals influence urate production, renal clearance, oxidative stress, and systemic inflammation, yet epidemiologic evidence linking mineral intake to gout is limited and rarely considers co-exposures. We analyzed six NHANES cycles (2007-2018) comprising 22,661 adults ≥ 20 years. After 1:1 propensity-score matching, usual intakes of nine dietary minerals were divided into quartiles. Survey-weighted multivariable logistic regression quantified single-mineral associations with gout. Weighted quantile sum (WQS) regression, quantile g-computation (qgcomp), and Bayesian kernel machine regression (BKMR) evaluated combined effects and potential interactions. In logistic regression analysis, only calcium showed a consistent inverse, dose-dependent relation with gout. For the highest versus lowest

SUBMITTER: Lai R 

PROVIDER: S-EPMC12597780 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature