Decoding immune-metabolic crosstalk in ARDS: a transcriptomic exploration of biomarkers, cellular dynamics, and therapeutic pathways.

ABSTRACT:

Background

Metabolic reprogramming plays a critical role in various diseases, with particular emphasis on immune cell metabolism. However, the involvement of immune cells and metabolic reprogramming-related genes (MRRGs) in acute respiratory distress syndrome (ARDS) remains underexplored. This study aimed to investigate the molecular mechanisms underlying cell and metabolic reprogramming biomarkers in ARDS.

Methods

Using transcriptomic data from whole blood samples, candidate genes were identified through differential expression analysis and weighted gene co-expression network analysis (WGCNA) in conjunction with MRRGs. Machine learning techniques, expression analysis, and receiver operating characteristic (ROC) analysis were employed to identify potential biomarkers. An art

SUBMITTER: Wu T 

PROVIDER: S-EPMC12597791 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature