Clinical characteristics and survival outcomes of extrapulmonary neuroendocrine carcinomas: a retrospective study.

ABSTRACT:

Background

Extrapulmonary neuroendocrine carcinomas (EPNECs) are rare, heterogeneous, and aggressive malignancies with limited evidence to guide management. This study aimed to investigate the clinical characteristics, prognostic factors, and treatment outcomes of EPNEC patients.

Methods

We retrospectively analyzed 343 EPNEC patients treated at Harbin Medical University Cancer Hospital from May 2011 to December 2023. Data on demographics, primary tumor sites, tumor markers (CEA and NSE), treatments, and survival were collected. Kaplan-Meier and Cox proportional hazards models were used to evaluate prognostic factors, and subgroup analyses were performed for treatment modalities.

Results

The median overall survival (OS) for the cohort was 23.7 months. Prognosis varied

SUBMITTER: Xu J 

PROVIDER: S-EPMC12597801 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature