Randomized pilot study of an individualized multimodal exercise, nutrition, and behavior intervention in breast cancer patients treated with ovarian function suppression: protocol proposal for The OvS Breast ENBI Project.

ABSTRACT:

Introduction

Breast cancer (BC) is the most common malignancy among women in Spain and worldwide. Ovarian function suppression (OFS) is recommended as an adjuvant strategy for high-risk hormone receptor (HR)-positive premenopausal BC patients. However, OFS is associated with unfavorable changes in body composition, weight gain, and adverse cardiorespiratory and emotional effects. Multimodal, individualized interventions integrating nutrition, exercise, and psycho-oncological support have demonstrated safety and efficacy in promoting healthy body composition, weight control, and cardiorespiratory fitness (CRF). This study aims to evaluate the impact of a personalized multicomponent intervention in premenopausal BC patients receiving adjuvant OFS.

Methods and analysis

We prese

SUBMITTER: Herrero Lopez B 

PROVIDER: S-EPMC12597807 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature