Cell-type- and locus-specific epigenetic editing of memory expression.

ABSTRACT: Epigenetic mechanisms have long been proposed to act as molecular mnemonics^1-3, but whether the epigenetic makeup of a single genomic site can guide learnt behaviors remains unknown. Here we combined CRISPR-based epigenetic editing tools^4,5 with c-Fos-driven engram technologies^6,7 to address this question in memory-bearing neuronal ensembles. Focusing on the promoter of Arc, which encodes a master regulator of synaptic plasticity⁸, we found that its locus-specific and temporally controlled epigenetic editing is necessary and sufficient to regulate memory expression. Such effects occurred irrespective of the memory phase-during the initially labile period after learning and for fully consolidated memories-and were reversible within subject, testif

SUBMITTER: Coda DM 

PROVIDER: S-EPMC12597831 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature