Teaching the laboratory assessment of neutrophil chemotaxis: a simulation-based approach for undergraduate immunology.

ABSTRACT: Neutrophils are essential cellular components of innate immunity. After injury, they migrate into tissues following chemotactic gradients to phagocytose pathogens or respond to tissue damage. This multistep process is tightly regulated, and defects at any stage can lead to increased bacterial infections. Identifying specific defects requires specialized assays, yet teaching the assessment of these functions in a laboratory setting presents challenges. At the University of South Australia, undergraduate immunology is taught to students training as laboratory medicine scientists, who must understand how to assess neutrophil function. However, demonstrating chemotaxis in the laboratory is not possible due to a lack of inverted microscopes, restricted laboratory time, and lack of patient sampl

SUBMITTER: Costabile M 

PROVIDER: S-EPMC12597877 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature