Synthetic bakuchiol derivatives: ester and ether analogs with activity against clinically important bacteria.

ABSTRACT:

Introduction

With the rise of antibiotic resistance and healthcare-associated infections, there is a growing need for alternative therapies. Otholobium glandulosum (L.) J.W. Grimes (= Psoralea glandulosa L.) (Fabaceae) and its active compound, bakuchiol, have demonstrated significant antimicrobial and biological potential. This study investigates bakuchiol-based synthetic derivatives as promising antibacterial agents against clinically relevant pathogens.

Methods

From the aerial parts of O. glandulosum, a resinous exudate was obtained, from which bakuchiol was isolated. This compound was used as a precursor to synthesize a series of ester-type (4-8) and ether-type (9-15) derivatives. All compounds were purified, their structures were confirmed by nuclear

SUBMITTER: Valdes F 

PROVIDER: S-EPMC12597907 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature