Senescent human fibroblasts have increased FasL expression and impair the tumor immune response.

ABSTRACT:

Introduction

Syngeneic mouse tumor models have shown that senescence influences the tumor immune response in multiple ways, including the induction of an immunosuppressive microenvironment or the promotion of immune cell recruitment. Yet, the impact of senescence on the tumor immune response in a humanized setting remains largely unexplored.

Methods

To address this question, we employed a combination cells co-culture models, tumor spheroids and mice bearing tumors immunogenic to human immune cells derived from the same donor.

Results

We found that senescent fibroblasts exert a dual effect by enhancing the recruitment of immune cells into the tumor microenvironment while simultaneously promoting the apoptosis of T and NK cells. Mechanistically, we demonstrate that this

SUBMITTER: Cruz-Barrera M 

PROVIDER: S-EPMC12597918 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature