Evaluation of febuxostat in treating diabetic kidney disease with hyperuricemia: a systematic review and meta-analysis of randomized controlled trials.

ABSTRACT:

Background

Diabetic kidney disease (DKD) combined with hyperuricemia (HUA) constitutes a pathological state of vicious cycle, where diabetic microvascular complications affect the kidneys and interact with persistent hyperuricemia. This condition significantly accelerates the progression of renal failure and increases all-cause mortality.

Objective

This study aims to systematically evaluate the clinical efficacy and safety of febuxostat in treating patients with DKD and HUA via a meta-analysis, thereby providing evidence-based guidance for optimizing clinical medication.

Methods

Following the PICOS principle, we systematically searched for randomized controlled trials (RCTs) on febuxostat for treating DKD combined with HUA, covering the period from the establishment o

SUBMITTER: Lin M 

PROVIDER: S-EPMC12597919 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature