Prolonged skin allograft survival by rM180 amelogenin in a murine skin transplantation model.

ABSTRACT:

Introduction

Amelogenin, used as a periodontal tissue regeneration material, promotes healing after periodontal surgery. A previous study has demonstrated that amelogenin is taken up by macrophages into the nucleus and inhibits major histocompatibility class II (MHC II) expression at the transcriptional level, thereby suppressing subsequent T cell activation. Therefore, in this study, we focused on the suppressive effect of amelogenin on MHC II expression and examined the effect of amelogenin on graft rejection following allogeneic skin transplantation in mice with different MHC II haplotype antigens.

Methods and results

Skin grafts were treated with recombinant murine amelogenin (rM180) and transplanted into recipient mice. The rM180-treated group showed a significant incre

SUBMITTER: Shida M 

PROVIDER: S-EPMC12597935 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature