The role of neutrophil-to-lymphocyte ratio in the prognosis of chronic kidney disease: insights from the NHANES cohort study.

ABSTRACT:

Objective

To investigate the association of neutrophil-to-lymphocyte ratio (NLR) with the cardiovascular disease (CVD) and all-cause mortality in patients with chronic kidney disease (CKD).

Methods

Using date from NHANES survey 2009-2018, 2,635 patients with CKD were eventually included in this study. The population was stratified into two groups based on the median NLR. Kaplan-Meier method with log-rank tests for significance was used for survival analysis. Weighted Cox proportional hazards regression models were employed to estimate the hazard ratio (HR) and corresponding 95% confidence interval (CI) for all-cause and CVD mortality. The potential nonlinear relationship between NLR and CVD and all-cause mortality was assessed using restricted cubic spline (RCS) models. The

SUBMITTER: Liu Y 

PROVIDER: S-EPMC12597963 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature