Effects of menopausal hormone therapy on gut microbiota in postmenopausal women and the relationship with bone metabolism.

ABSTRACT:

Objectives

Menopausal Hormone Replacement Therapy (MHT) is widely used by peri- and post-menopausal women to alleviate menopause-related symptoms and preventing bone loss, but the underlying mechanisms remain inadequately elucidated. Accumulating evidence suggested that gut microbiota was involved in the regulation of bone metabolic processes. The aim of this study was to characterize the alterations in gut microbiota profiles by MHT treatment in postmenopausal women and explore the relationship between gut microbiota and bone metabolism.

Methods

Fecal samples collected from a total of 31 postmenopausal women with or without MHT were subjected to 16S ribosomal RNA (rRNA) gene sequencing and short-chain fatty acid (SCFAs) analysis in this study. The serum levels of bone metab

SUBMITTER: Xiong J 

PROVIDER: S-EPMC12597987 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature