Comparative <i>in vitro</i> susceptibility of clinical <i>Leishmania</i> isolates to miltefosine and oleylphosphocholine.

ABSTRACT: Cutaneous leishmaniasis (CL) is a neglected tropical disease caused by protozoan parasites of the genus Leishmania. It poses a significant global health burden, particularly because treatment options are limited. More effective and safer treatments are urgently needed. In previous studies, oleylphosphocholine (OlPC), a novel investigational compound structurally related to miltefosine, exhibited comparable activity to miltefosine in intramacrophage assays across various CL-causing laboratory strains and demonstrated superior efficacy in an experimental CL model. This study investigated the in vitro activity of OlPC against clinical isolates of Leishmania spp., comparing its activity with standard anti-leishmanial drugs, including miltefosine, amphotericin B, and pentav

SUBMITTER: Khamesipour A 

PROVIDER: S-EPMC12598013 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature