Study on Chaiyuwendan decoction's inhibition of hippocampal neuron apoptosis to alleviating depression by activating the AKT/CREB pathway.

ABSTRACT:

Background

Hippocampal neuron damage is closely related to depression, and apoptosis is an important pathway for neuronal damage. Depression belongs to Yubing (depressive disease) in traditional Chinese medicine theory. Chaiyuwendan decoction (CYWD) has significant clinical efficacy in treating depression, however, its specific mechanism is still unclear. This study aims to explore the potential pharmacological active substances and key therapeutic targets of CYWD in treating depression from signaling pathways related with apoptosis.

Methods

HPLC-MS method was used to detect the key components of CYWD. The mouse depression model was established by CORT injection. Depressive mice were administered CYWD at low, medium and high doses. Behavioral experiment, neurotransmitters in

SUBMITTER: Zhang S 

PROVIDER: S-EPMC12598031 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature