B-Type Natriuretic Peptides Levels in Patients With Beta-Thalassemia Major and Correlations With Biomarkers: A Systematic Review and Meta-Analysis.

ABSTRACT:

Background

Patients with beta-thalassemia major are prone for developing cardiovascular complications. Early identification of patients at risk is important. B-type natriuretic peptides such as brain natriuretic peptide (BNP) and N-terminal pro-BNP (NT-proBNP) are sensitive indicators of cardiac dysfunction. This review synthesizes the existing evidence on the levels of B-type natriuretic peptides in beta-thalassemia major and their relationship with markers of cardiac dysfunction and other biomarkers.

Methods

A systematic review was conducted according to PRISMA guidelines. The search was performed in the PubMed, Web of Science, ScienceDirect, and World Health Organization Virtual Health Library Regional Portal. Pooled standardized mean differences (SMD) and correlation coe

SUBMITTER: Salih MSK 

PROVIDER: S-EPMC12598194 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature