Targeting Progesterone Receptor Membrane Component 1 to Improve Muscle Development and Glucose Homeostasis.

ABSTRACT:

Background

Type 2 diabetes mellitus (T2D) arises from the interplay between peripheral insulin resistance and pancreatic β-cell dysfunction, ultimately leading to impaired glucose utilization and chronic hyperglycemia. Despite therapeutic advances, the multifactorial nature of T2D continues to demand the development of novel treatment strategies. Progesterone receptor membrane component 1 (PGRMC1) has emerged as a potential modulator of metabolic function, though its role in T2D pathogenesis has not been fully elucidated.

Methods

To investigate the role of PGRMC1 in T2D, we generated skeletal muscle-specific Pgrmc1 knockout (PKO) mice (ACTA^cre-Pgrmc1^fl/fl). T2D was induced via a high-fat diet combined with streptozotocin (HFD-STZ) or using genetically d

SUBMITTER: Lee SR 

PROVIDER: S-EPMC12598302 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature