Microbial and Metabolomic Variations Correlated With Gastric Cancer Subtypes and Prognosis.

ABSTRACT: Gastric cancer (GC) persists as the third most prevalent malignancy in China. GC exhibits distinct features when stratified by Lauren/ZJU subtypes. The interdependence of microbes, metabolites, and tumor evolution is recognized. Nevertheless, the specific microbial and metabolite disparities related to the Lauren and ZJU subtypes of GC have yet to be thoroughly investigated. In this study, we employed 16S sequencing of microbial communities and conducted untargeted metabolomic assessments on tumor tissues and their matched normal controls from 50 GC patients. We observed variations in microbial composition and metabolite landscapes across subtypes, irrespective of the Lauren or ZJU classification. We explored the associations and differences between the Lauren and the ZJU classification. I

SUBMITTER: Yang Y 

PROVIDER: S-EPMC12598303 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature