Molecular and clinical registry of Chilean patients diagnosed with BRAF-mutated colorectal cancer.

ABSTRACT:

Background

In recent years, the epidemiological trend of colorectal cancer (CRC) in Chile has become increasingly concerning, particularly due to the high costs associated with managing advanced-stage disease, which places a significant strain on the national healthcare system. In 2012, 2,417 new CRC cases were reported across both sexes in Chile. However, current projections estimate a sharp rise to 5,914 new cases, corresponding to an incidence rate of 20.7 per 100,000 individuals. This study aims to register the presence of BRAF mutations in Chilean patients to better characterize the molecular epidemiology of CRC in the local population. BRAF mutations are associated with poor prognosis, with affected patients typically exhibiting a median overall survival (OS) of

SUBMITTER: Garcia-Bloj B 

PROVIDER: S-EPMC12598326 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature