ISM2 as a prognostic biomarker and mediator of immune infiltration in colorectal cancer: evidence from bioinformatics and experimental analysis.

ABSTRACT:

Background

Colorectal cancer (CRC) is a significant global health concern due to its high incidence and increasing prevalence among younger individuals. The identification of reliable biomarkers is essential for improving diagnostic accuracy and optimizing therapeutic strategies. Isthmin 2 (ISM2), a member of the Isthmin protein family, is expressed in multiple tissues, but its specific role in tumorigenesis and cancer progression remains poorly understood. Aberrant ISM2 expression has been detected in several malignancies, suggesting its potential involvement in cancer biology. Consequently, exploring the role of ISM2 in CRC is of great significance. This study aimed to explore the role of ISM2 in CRC, including its expression patterns, clinical significance, association with immu

SUBMITTER: Qiang WH 

PROVIDER: S-EPMC12598330 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature