Disparities in gastrointestinal cancer trials recruitment: analyzing demographic gaps compared to the real-world.

ABSTRACT:

Background

Gastrointestinal (GI) cancers are a leading cause of morbidity and mortality worldwide, accounting for a substantial portion of cancer incidence and cancer-related deaths. Randomized clinical trials (RCTs) are fundamental to the development of new therapies, as they generate evidence on efficacy and safety. However, concerns persist regarding whether trial populations accurately reflect the demographics of real-world patient populations, including variations by age, sex, race, and ethnicity. Underrepresentation of specific subgroups, such as older adults, racial/ethnic minorities, or those with distinct biological risk factors, can limit the external validity of trial findings and impede equitable treatment outcomes. As global populations become increasingly diverse and

SUBMITTER: Ghusn W 

PROVIDER: S-EPMC12598342 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature