Effects of current smoking on treatment outcomes in metastatic and locally advanced pancreatic carcinoma: a retrospective cohort study using the international PURPLE pancreas cancer registry.

ABSTRACT:

Background

Tobacco smoking accounts for 22% of the pancreatic cancer burden in Australia. Smoking may increase therapy-related adverse effects and was associated with shorter survival in the previous analysis of all stages of pancreatic cancer. There is ongoing uncertainty among clinicians regarding the benefits of encouraging smoking cessation in patients with advanced cancer. The objective of this study was to evaluate the association between current smoking and survival outcomes in patients with advanced pancreatic cancer using real-world registry data.

Methods

We studied the impact of ongoing smoking on survival among patients with metastatic and locally advanced pancreatic carcinoma in the Pancreatic Cancer: Understanding Routine Practice & Lifting End Results (PURPLE)

SUBMITTER: Hayat F 

PROVIDER: S-EPMC12598346 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature