Evaluating the cross-reactivity of a stool methylated syndecan-2 (me<i>SDC2</i>) test in colorectal cancer detection.

ABSTRACT:

Background

A stool methylated syndecan-2 (meSDC2) test has demonstrated high sensitivity and specificity in diagnosing colorectal cancer (CRC). We aimed to evaluate the cross-reactivity of the meSDC2 test through multi-cancer analysis.

Methods

This study is a prospective, single-centre study. We recruited patients with 13 different types of cancers, including CRC, as positive control. Excluding those with CRC, participants did not undergo colonoscopy. Stool samples were collected from each patient before starting definitive therapy for each cancer and sent to the central lab for methylation analysis. We investigated the cancer incidence rates based on Korean cancer statistics to infer the predicted positivity rates for each cancer type.

Results

A total o

SUBMITTER: Hong SW 

PROVIDER: S-EPMC12598348 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature