STRIP2 promotes hepatocellular carcinoma progression and immune evasion: a potential prognostic biomarker and therapeutic target.

ABSTRACT:

Background

STRIP2 is a key regulator of cytoskeletal dynamics, yet its precise role in hepatocellular carcinoma (HCC) remains unclear. This study aimed to elucidate the mechanistic function of STRIP2 in HCC progression.

Methods

STRIP2 expression was analyzed using public databases. The prognostic significance and predictive value of STRIP2 were assessed through Kaplan-Meier survival analysis, receiver operating characteristic (ROC) curves, univariate and multivariate Cox regression, and nomogram models. Enrichment analysis was performed to explore STRIP2-related signaling pathways. Immune infiltration analysis was conducted to examine the relationship between STRIP2 and the tumor immune microenvironment. Tumor Immune Dysfunction and Exclusion (TIDE) scores and drug sensitivi

SUBMITTER: Yang W 

PROVIDER: S-EPMC12598350 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature