Expression and clinical significance of <i>ERBB4</i> in gastric cancer.

ABSTRACT:

Background

Despite being the fourth leading cause of cancer deaths globally, advanced gastric cancer (GC) lacks effective therapeutic targets. While HER2-targeted therapy benefits a subset of patients, the role of its homolog ERBB4 remains controversial in GC pathogenesis and prognosis. This study aimed to examine the expression of ERBB4 in GC and explore whether it could serve as a new target for the biological therapy of GC.

Methods

Sequencing and clinical data on the ERBB4 gene in GC (tumor) tissues and adjacent non-cancerous (normal) tissues were downloaded from The Cancer Genome Atlas (TCGA) database. A differential expression analysis of the collected ERBB4 gene expression data was conducted. The ERBB4 expression profile in GC

SUBMITTER: Zhou X 

PROVIDER: S-EPMC12598360 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature