DNA methylation landscapes of HIV controllers: an epigenome-wide association study.

ABSTRACT:

Background

Spontaneous control of HIV infection without anti-retroviral therapy (ART) is a rare phenomenon observed in a small subset of people living with HIV (PWH), yet its underlying mechanisms remain poorly understood. Epigenetic modifications, particularly DNA methylation, may contribute to this unique phenotype.

Methods

Here, we present an epigenome-wide association study (EWAS) analysing whole-blood DNA methylation profiles from the 2000HIV study, which includes HIV controllers (n = 111)-comprising elite controllers (ECs), viraemic controllers (VCs), transient controllers (TCs), and persistent controllers (PCs)- and virally suppressed PWH using ART (NHCs, n = 1667), from diverse ethnic backgrounds. The majority of participants (n = 1345) were of Western European desce

SUBMITTER: Gupta MK 

PROVIDER: S-EPMC12598396 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature