The Imbalanced Patterns and Clinical Significance of Cytokines in Acute Myeloid Leukemia Microenvironment.

ABSTRACT:

Introduction

Acute myeloid leukemia (AML) is known for its unfavorable prognosis, prompting research efforts of cytokines in the microenvironment to explore new therapeutic targets. Here, we investigated the complex cytokine networks in both AML mice and AML patients to reveal the role of cytokines in AML pathogenesis.

Methods

As a basis for further studies on human, the patterns of cytokines were detected in AML mice by cytokine array panel, and the patterns of cytokines were detected in AML patients by Luminex liquid suspension chip and ELISA. Leukocyte subpopulations in human were analyzed by flow cytometry. Additionally, the associations of cytokine levels with the outcome of AML patients were analyzed by Cox regression analysis, the overall survival curve was assessed b

SUBMITTER: Wang R 

PROVIDER: S-EPMC12598404 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature