Microwave-assisted multi-component green synthesis of bioactive pyrazol-5-ol and its derivatives using graphene oxide as a recyclable catalyst: a route to EGFR inhibitors.

ABSTRACT: Traditional methods for synthesizing heterocyclic compounds often involve multistep procedures and harsh conditions, leading to environmental concerns and inefficient use of resources. Herein, a sustainable and rapid microwave-assisted multi-component reaction (MCR) strategy was developed for the synthesis of 3-methyl-4-(2-nitro-1-phenylethyl)-1H-pyrazol-5-ol (4) using graphene oxide (GO) as a heterogeneous catalyst in various polar solvents. Under optimized conditions (180 W, 4 min, 0.05 wt% GO in water), the reaction afforded up to 95% yield. GO, synthesized via a modified Hummers' method, exhibited excellent catalytic efficiency and reusability over five consecutive cycles with minimal loss of activity. Structural analyses (XRD, XPS, Raman, FT-IR, TGA, and TEM) revealed th

SUBMITTER: Chaudhari D 

PROVIDER: S-EPMC12598462 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature