Host Translational Control by Stress Granules Promotes <i>Mycobacterium tuberculosis</i> Pathogenesis.

ABSTRACT: Stress granules (SGs) are cytoplasmic condensates that regulate mRNA translation and signaling in response to stress. Although SGs have been widely studied in antiviral responses, their function in bacterial infections is not well understood. Here, we demonstrate that SGs promote Mycobacterium tuberculosis (Mtb) pathogenesis by suppressing mitochondrial metabolism and innate immunity. Quantitative proteomics revealed that Mtb-induced SGs sequester mTORC1 and suppress cap-dependent mRNA translation. This leads to decreased expression of proteins necessary for mitochondrial respiration and immune activation in bone marrow-derived macrophages (BMDMs). Disrupting SG assembly restored mTORC1 signaling, enhanced oxidative phosphorylation, and increased the production of antimicrobial medi

SUBMITTER: Kim J 

PROVIDER: S-EPMC12598499 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature