Cu-catalyzed enantioconvergent oxygen-centered radical cyclization.

ABSTRACT: Radical asymmetric cyclization has emerged as a powerful strategy for constructing ring structures. Despite significant progress in carbon-centered radical cyclization, the catalytic asymmetric cyclization of oxygen-centered radicals, key species in many biological processes, remains challenging owing to their high oxidizing power and electrophilicity. Herein, we report an enantioconvergent oxygen-centered radical cyclization via Cu-catalyzed asymmetric C(sp³)-O oxidative coupling between the tertiary C(sp³)-H bond and the oxime O-H bond of racemic γ-ketoximes. This radical reaction proceeds efficiently under aerobic and mild conditions, affording a wide range of valuable isoxazolines bearing a fully substituted stereocenter in good yields with excellent enanti

SUBMITTER: Li ZY 

PROVIDER: S-EPMC12598502 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature