Stimulator of interferon genes signaling network-driven prognostic signature for pancreatic cancer: Hub gene discovery with multimodal validation.

ABSTRACT: The stimulator of interferon genes (STING) signaling pathway plays an important role in tumor progression, particularly in immune regulation. However, the functions of STING-related genes in immunologically 'cold' tumors, such as pancreatic ductal adenocarcinoma (PAAD), are yet to be elucidated. The present study aims to investigate the involvement of STING signaling pathway-associated genes in PAAD progression and immune infiltration. Bioinformatics analysis of PAAD transcriptomic data from public cohorts (TCGA and GEO) revealed that the majority of STING-related genes were highly expressed in PAAD. Based on the expression levels of these genes, patients with PAAD from these cohorts were stratified into high-risk and low-risk groups. These STING-related genes exerted differential impacts

SUBMITTER: Yu W 

PROVIDER: S-EPMC12598526 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature