Prognostic significance of ductal carcinoma <i>in situ</i> coexisting with invasive ductal carcinoma: Biological behavior, immune response and survival outcomes.

ABSTRACT: Biological differences exist between invasive ductal carcinoma (IDC) and IDC + ductal carcinoma in situ (DCIS) tumors including variations in tumor grade, hormone receptor status, human epidermal growth factor receptor 2 (HER2) expression, proliferative activity and molecular subtype. The present study evaluated the impact of the coexistence of IDC + DCIS on tumor microenvironment, tumor-infiltrating lymphocytes (TILs), clinical and pathological features, prognosis and survival. A total of 165 patients with IDC and 404 with IDC + DCIS were enrolled and treated in the outpatient clinic, Hacettepe University Department of Medical Oncology (Ankara, Turkey) between January 2014 and July 2021. Compared with IDC, patients with IDC + DCIS were more likely to be hormone receptor-positive an

SUBMITTER: Fedai NK 

PROVIDER: S-EPMC12598529 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature