Detection of <i>SHOX2</i> and <i>RASSF1A</i> methylation for early-stage lung adenocarcinoma.

ABSTRACT: Lung cancer (LC) is the most common malignant tumor globally, and lung adenocarcinoma (LUAD) represents the most common pathologic subtype. The DNA methylation of Short Stature Homeobox 2 (SHOX2) and Ras Association Domain Family 1 Isoform A (RASSF1A) showed the potential of diagnosing LC. With the aim of investigating the diagnostic value of SHOX2 and RASSF1A methylation in early-stage LUAD, 50 lung tissue specimens from patients suffering from early-stage LUAD were analyzed, including 25 tumor tissue specimens and 25 paired non-tumor lung tissue specimens. The methylation status of SHOX2 and RASSF1A was assessed by using methylation-specific PCR. The results showed significantly elevated methylation status of SHOX2 and RASSF1A in tumor tissues compared with non-tumor tissues. The sensiti

SUBMITTER: Chen Y 

PROVIDER: S-EPMC12598544 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature