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Millimeter-scale fluid-driven soft robots.


ABSTRACT: Millimeter-scale soft robots (milli-SRs) promise significant advancements in biomedical engineering and inspection, enabling precise navigation in confined spaces. However, fabricating miniaturized fluid-driven soft robots is hindered by microscale forces. Here, we introduce a new universal design and fabrication approach (referred to as the mini bubble casting method) to create high-quality multifunctional fluid-driven milli-SRs. By injecting a bubble into pre-modified silicone liquid under high-stability conditions, we achieve submillimeter internal voids, overcoming interfacial-tension-induced instability. The modification strategy is guided by our theoretical model, which explains the influence of viscous resistance and interfacial tension on the dynamic behavior of the bubble-silicone interface. We successfully fabricate soft milli-actuators ten times smaller than existing works with low surface smoothness ([Formula: see text] nm). We demonstrate a milli-gripper handling delicate insects and a thrombus extractor for narrow vessels. We present a miniature steerable tip for bronchial navigation, improving safety and dexterity over traditional tools, showing the tremendous biomedical potential of these devices.

SUBMITTER: Bian R 

PROVIDER: S-EPMC12598632 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature

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Millimeter-scale fluid-driven soft robots.

Bian Rong R   Zhang Ningbin N   Yang Xinyu X   Li Jinhao J   Yang Dezhi D   Ren Jieji J   Zou Jiang J   Gu Guoying G  

National science review 20250929 11


Millimeter-scale soft robots (milli-SRs) promise significant advancements in biomedical engineering and inspection, enabling precise navigation in confined spaces. However, fabricating miniaturized fluid-driven soft robots is hindered by microscale forces. Here, we introduce a new universal design and fabrication approach (referred to as the mini bubble casting method) to create high-quality multifunctional fluid-driven milli-SRs. By injecting a bubble into pre-modified silicone liquid under hig  ...[more]

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