Dual Structural Role of Niobium in Bioactive Borate Glasses Modulates Bioactivity, Cytocompatibility, and Hemostatic Potential.

ABSTRACT: Designing bioactive glasses with tunable biological responses requires a precise understanding of how network modifiers influence structure-property relationships. This work investigates the effect of incorporating niobium pentoxide (Nb₂O₅) into melt-derived borate glasses, aiming to uncover how Nb affects the glass structure and its multifunctional biological performance. Glasses with nominal compositions: 60B₂O₃-(19-x/2)CaO-(19-x/2)Na₂O-2P₂O₅-xNb₂O₅ (x = 0, 2.5, 5, 7.5, and 10 wt %) were synthesized and comprehensively characterized. A key finding is the dual structural role of Nb: it predominantly acts as a network former at ≤5 wt % and as a network modifier at

SUBMITTER: Gibbin MS 

PROVIDER: S-EPMC12598716 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature