Investigating the roles of microRNAs associated with cancer stem cells, drug resistance, metastasis and recurrence in hepatocellular carcinoma: A systematic review, network analysis and experimental verification.

ABSTRACT: Cancer stem cells (CSCs) are responsible for drug therapy resistance, recurrence and metastasis in hepatocellular carcinoma (HCC). Certain microRNAs (miRNAs/miRs) are involved in various pathological cancer pathways via their binding interactions with target mRNAs. The objectives of the present study were to explore the potential microRNAs associated with HCC-CSCs, and to investigate their roles in recurrence, metastasis and drug resistance. Initially, a registered systematic review (CRD42024508526; International Prospective Register of Systematic Reviews) identified a group of miRNAs associated with HCC prognosis, and the Coremine Medical data mining tool identified another group of potential miRNAs associated with HCC-CSCs, recurrence, metastasis and drug resistance. Secondly, potential

SUBMITTER: Jiang Y 

PROVIDER: S-EPMC12598727 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature