Obesity accelerates brain ageing: a multimodal imaging study.

ABSTRACT: Obesity is a global health concern, and it is thought to accelerate the normal ageing process. Obesity has also been linked to neurodegenerative processes, possibly as a manifestation of accelerated brain-ageing. In this cross-sectional study we combined multimodal neuroimaging data and machine learning techniques to assess the discrepancy between brain-based predicted age and chronological age, known as brain age delta, in obese participants and in normal-weighted individuals using a tight matching for age, gender and education across groups. Data were taken from the publicly available dataset 'The Cambridge Centre for Ageing and Neuroscience (Cam-CAN)' covering the adult lifespan (18-90 years old). Overall, brain age delta was greater in obese individuals for grey matter (GM) and

SUBMITTER: Vanni F 

PROVIDER: S-EPMC12598755 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature