Dynamic relationship between cerebrospinal fluid immune cells and tissue damage markers in multiple sclerosis.

ABSTRACT: Multiple sclerosis (MS) is characterized by immune-mediated demyelination and neurodegeneration. While cerebrospinal fluid (CSF) biomarkers can track tissue damage, the relationship between immune cell populations and tissue damage markers remains poorly understood. We performed comprehensive immunophenotyping of CSF samples from 63 participants [29 relapsing-remitting multiple sclerosis (RRMS), 7 primary progressive multiple sclerosis (PPMS), 27 patients with other suspected neurological diseases (OND)]. CSF levels of neurofilament light chain (NfL) and glial fibrillary acidic protein (GFAP) were measured using single-molecule array technology. Relationships between immune cell populations and biomarkers were assessed using partial correlation and multiple regression analyses, adjusting f

SUBMITTER: Zaic S 

PROVIDER: S-EPMC12598767 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature