Quercetin-Loaded Graphene Oxide Nanoparticles Modulate Inflammatory Gene Expression and Enhance Cell Migration In Vitro.

ABSTRACT: Quercetin, a plant-derived flavonoid, shows promising wound-healing properties due to its antioxidant, anti-inflammatory, and antibacterial effects. However, its limited water solubility limits its use. This study aims to enhance quercetin's efficacy by loading it onto graphene oxide (GO) and evaluating its in vitro effects for wound healing. GO is synthesized and quercetin is loaded onto its surface. Cytotoxicity of GO, quercetin, and quercetin-loaded GO on human foreskin fibroblasts is determined. The expression levels of genes NF-κB, IL-1β, and TNF-α are measured using qPCR. Wound healing is assessed via a scratch assay. The minimum inhibitory concentration (MIC) and maximum bactericidal concentration (MBC) of GO and quercetin-loaded GO against E. coli and S. aureus are determined. Resu

SUBMITTER: Alipour H 

PROVIDER: S-EPMC12598803 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature