Unimodal Imaging of Monovalent Metal-Chelator Complexes and Lipids by MALDI Imaging Mass Spectrometry.

ABSTRACT: Careful regulation of monovalent metal ions (M⁺) is necessary to maintain a functional cellular system. Of these ions, appropriate sodium (Na⁺) and potassium (K⁺) concentrations are particularly integral for electrochemical signaling, as well as the secondary transport of nutrients and waste. Dysregulation of M⁺ homeostasis can disrupt these mechanisms, potentially influencing the metabolism of downstream biomolecules such as lipids. Thus, the relationship between M⁺ abundances and related biomolecular distributions must be elucidated to better understand the physiology of healthy and disordered tissues. Traditional techniques for imaging biological metal distributions include SIMS, LA-ICP-MS, and XRF; however, these capabilities are l

SUBMITTER: Luchini KA 

PROVIDER: S-EPMC12598849 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature