Defining the pH* Scale in Methanol: Determination of Accurate Values for the Solvation Free Energies of CH₃OH₂⁺ and CH₃O^- in Methanol.

ABSTRACT: A correction factor for the autoprotolysis constant of methanol is proposed in the present work to obtain thermodynamic data for the standard solvation free energies of CH₃OH₂⁺ and CH₃O^- ions in methanol and pK_a^*. Using this corrected constant, K_MOH^*, along with known values for the standard solvation free energy of proton ΔG_sol^*(H⁺) and of the methanol molecule ΔG_sol^*(CH₃OH), in its own liquid, in three different thermodynamic cycles, we obtain ΔG_sol^*(CH₃OH₂⁺) = -91.41 ± 2.76 kcal mol^-1, ΔG_sol^*(CH

SUBMITTER: Cunha AR 

PROVIDER: S-EPMC12598864 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature