A Comparative Study of Virucidal and Virustatic Multivalent Entry Inhibitors.

ABSTRACT: Viral infections, such as those caused by herpes simplex viruses (HSV) and influenza, continue to pose a significant global health challenge. We have focused on the development of multivalent entry inhibitors (MEIs) that have an irreversible inhibition mechanism, i.e., virucidal, as opposed to the commonly found reversible virustatic ones. MEIs are typically composed of core structures connected to multiple functional groups that are engineered to bind to viruses. In between the core and the functional groups, we inserted alkyl linkers and showed that such linkers, when long enough, were responsible for a change in the inhibition mechanism by their hydrophobicity. In a recent paper, we found that comparison of the antiviral properties against HSV-2 of one pair of sulfonate and sulfate MEIs

SUBMITTER: Tran HT 

PROVIDER: S-EPMC12598866 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature